Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Nephrotic syndrome
ADR ID BADD_A03027
ADR Hierarchy
20      Renal and urinary disorders
20.05      Nephropathies
20.05.01      Glomerulonephritis and nephrotic syndrome
20.05.01.002      Nephrotic syndrome
Description A disorder characterized by symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction. [CTCAE] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA. [MeSH]
MedDRA Code 10029164
MeSH ID D009401; D009404; D009404
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Nephrosis | Nephrosis osmotic | Nephrotic syndrome | Nephrotic syndrome in diseases classified elsewhere | Nephrotic syndrome with lesion of membranoproliferative glomerulonephritis | Nephrotic syndrome with lesion of membranous glomerulonephritis | Nephrotic syndrome with lesion of minimal change glomerulonephritis | Nephrotic syndrome with lesion of proliferative glomerulonephritis | Nephrotic syndrome with other pathological lesion in kidney | Nephrotic syndrome with other specified pathological lesion in kidney | Nephrotic syndrome with unspecified pathological lesion in kidney | Syndrome nephrotic | Nephrotic syndrome worsened | Steroid-resistant nephrotic syndrome | Nephroses
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01130Idelalisib0.000139%
BADD_D01136Imatinib0.000799%
BADD_D01144Immunoglobulin (human)--
BADD_D01145Immunoglobulin g (human)--
BADD_D01156Indomethacin--
BADD_D01167Interferon alfa-2b--
BADD_D01181Iopamidol--
BADD_D01204Isoniazid0.031851%
BADD_D01231Ketoprofen--
BADD_D01233Ketorolac tromethamine--
BADD_D01242Lamivudine0.004638%
BADD_D01253Lenalidomide--
BADD_D01254Lenvatinib0.005328%
BADD_D01257Letrozole0.001846%
BADD_D01258Leucovorin0.011662%
BADD_D01265Levetiracetam--
BADD_D01275Levofloxacin0.000607%
BADD_D01295Linezolid0.003937%
BADD_D01349Mannitol--
BADD_D01366Medroxyprogesterone acetate--
BADD_D01368Mefenamic acid--
BADD_D01374Meloxicam0.000147%
BADD_D01386Mephenytoin--
BADD_D01397Mesalamine--
BADD_D01401Metformin--
BADD_D01431Methylphenidate0.000367%
BADD_D01435Methylprednisolone hemisuccinate0.013989%
BADD_D01445Metoprolol0.000031%
BADD_D01496Montelukast0.000174%
BADD_D01507Mycophenolate mofetil0.013078%
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